Clinico-radiological spectrum of reversible splenial lesions in children.
Identifieur interne : 001D16 ( Main/Exploration ); précédent : 001D15; suivant : 001D17Clinico-radiological spectrum of reversible splenial lesions in children.
Auteurs : Mitsuru Kashiwagi [Japon] ; Takuya Tanabe [Japon] ; Shuichi Shimakawa [Japon] ; Michiko Nakamura [Japon] ; Shinya Murata [Japon] ; Kousuke Shabana [Japon] ; Jun Shinohara [Japon] ; Yutaka Odanaka [Japon] ; Hideki Matsumura [Japon] ; Koh Maki [Japon] ; Kenichi Okumura [Japon] ; Keisuke Okasora [Japon] ; Hiroshi Tamai [Japon]Source :
- Brain & development [ 1872-7131 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse chimique du sang, Corps calleux (anatomopathologie), Crises convulsives fébriles (), Crises convulsives fébriles (diagnostic), Crises convulsives fébriles (physiopathologie), Crises convulsives fébriles (étiologie), Encéphalopathies (), Encéphalopathies (diagnostic), Encéphalopathies (physiopathologie), Encéphalopathies (étiologie), Enfant, Enfant d'âge préscolaire, Femelle, Fièvre (), Humains, Imagerie par résonance magnétique, Mâle, Nourrisson, Pronostic, Récidive, Syndrome, Électroencéphalographie, Études rétrospectives, Évolution de la maladie.
- MESH :
- anatomopathologie : Corps calleux.
- diagnostic : Crises convulsives fébriles, Encéphalopathies.
- physiopathologie : Crises convulsives fébriles, Encéphalopathies.
- étiologie : Crises convulsives fébriles, Encéphalopathies.
- Analyse chimique du sang, Crises convulsives fébriles, Encéphalopathies, Enfant, Enfant d'âge préscolaire, Femelle, Fièvre, Humains, Imagerie par résonance magnétique, Mâle, Nourrisson, Pronostic, Récidive, Syndrome, Électroencéphalographie, Études rétrospectives, Évolution de la maladie.
English descriptors
- KwdEn :
- Blood Chemical Analysis, Brain Diseases (diagnosis), Brain Diseases (etiology), Brain Diseases (physiopathology), Brain Diseases (therapy), Child, Child, Preschool, Corpus Callosum (pathology), Disease Progression, Electroencephalography, Female, Fever (complications), Humans, Infant, Magnetic Resonance Imaging, Male, Prognosis, Recurrence, Retrospective Studies, Seizures, Febrile (diagnosis), Seizures, Febrile (etiology), Seizures, Febrile (physiopathology), Seizures, Febrile (therapy), Syndrome.
- MESH :
- complications : Fever.
- diagnosis : Brain Diseases, Seizures, Febrile.
- etiology : Brain Diseases, Seizures, Febrile.
- pathology : Corpus Callosum.
- physiopathology : Brain Diseases, Seizures, Febrile.
- therapy : Brain Diseases, Seizures, Febrile.
- Blood Chemical Analysis, Child, Child, Preschool, Disease Progression, Electroencephalography, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Prognosis, Recurrence, Retrospective Studies, Syndrome.
Abstract
Recently, many cases of children presenting reversible splenial lesions during febrile illness (RESLEF) have been reported; however, their overall clinico-radiological features are unclear. To describe the clinico-radiological features, we retrospectively reviewed the etiology (pathogen), clinical course, laboratory data, magnetic resonance imaging and electroencephalography (EEG) findings, therapy, and prognosis of 23 episodes in 22 children (1 child recurred) who presented neurological symptoms, with RESLEF. The etiologies (pathogens) varied. Seizure occurred in 7 episodes, disturbance of consciousness (DC) in 13, and delirious behavior in 18. Serum sodium levels <136 mEq/L were observed in 18 episodes. Lesions outside the splenium were found in 4 cases. Slow waves were observed on EEG in 10 episodes. Methylprednisolone pulse therapy was given in 7 cases. No case resulted in neurological sequelae. Among 23 episodes, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) was diagnosed in 6 episodes, whereas non-MERS was observed in 17 episodes. No difference was observed in almost all the clinico-radiological features' data between the 2 groups. The largest differences were observed in the rate of purposeless movement, DC, extension of the abnormal lesions outside the splenium, and marked slowing of background activity on EEG. RESLEF exhibit a spectrum of clinico-radiological features. These results suggest that non-MERS and MERS both are a part of a larger pathological condition, which we have termed as RESLEF spectrum syndrome. Given the view that such a syndrome exists, the clinical characteristics and position of non-MERS and MERS become clear.
DOI: 10.1016/j.braindev.2013.05.007
PubMed: 23790266
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001C75
- to stream PubMed, to step Curation: 001C75
- to stream PubMed, to step Checkpoint: 001966
- to stream Ncbi, to step Merge: 000A64
- to stream Ncbi, to step Curation: 000A64
- to stream Ncbi, to step Checkpoint: 000A64
- to stream Main, to step Merge: 001D30
- to stream Main, to step Curation: 001D16
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinico-radiological spectrum of reversible splenial lesions in children.</title><author><name sortKey="Kashiwagi, Mitsuru" sort="Kashiwagi, Mitsuru" uniqKey="Kashiwagi M" first="Mitsuru" last="Kashiwagi">Mitsuru Kashiwagi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan. Electronic address: dbs003@art.osaka-med.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tanabe, Takuya" sort="Tanabe, Takuya" uniqKey="Tanabe T" first="Takuya" last="Tanabe">Takuya Tanabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Child Neurology, Tanabe Kadobayashi Children's Clinic, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Child Neurology, Tanabe Kadobayashi Children's Clinic</wicri:regionArea><wicri:noRegion>Tanabe Kadobayashi Children's Clinic</wicri:noRegion></affiliation></author><author><name sortKey="Shimakawa, Shuichi" sort="Shimakawa, Shuichi" uniqKey="Shimakawa S" first="Shuichi" last="Shimakawa">Shuichi Shimakawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Michiko" sort="Nakamura, Michiko" uniqKey="Nakamura M" first="Michiko" last="Nakamura">Michiko Nakamura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Murata, Shinya" sort="Murata, Shinya" uniqKey="Murata S" first="Shinya" last="Murata">Shinya Murata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Shabana, Kousuke" sort="Shabana, Kousuke" uniqKey="Shabana K" first="Kousuke" last="Shabana">Kousuke Shabana</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Shinohara, Jun" sort="Shinohara, Jun" uniqKey="Shinohara J" first="Jun" last="Shinohara">Jun Shinohara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Odanaka, Yutaka" sort="Odanaka, Yutaka" uniqKey="Odanaka Y" first="Yutaka" last="Odanaka">Yutaka Odanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Nagano Children's Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Nagano Children's Hospital</wicri:regionArea><wicri:noRegion>Nagano Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Matsumura, Hideki" sort="Matsumura, Hideki" uniqKey="Matsumura H" first="Hideki" last="Matsumura">Hideki Matsumura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Maki, Koh" sort="Maki, Koh" uniqKey="Maki K" first="Koh" last="Maki">Koh Maki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Okumura, Kenichi" sort="Okumura, Kenichi" uniqKey="Okumura K" first="Kenichi" last="Okumura">Kenichi Okumura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Okasora, Keisuke" sort="Okasora, Keisuke" uniqKey="Okasora K" first="Keisuke" last="Okasora">Keisuke Okasora</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tamai, Hiroshi" sort="Tamai, Hiroshi" uniqKey="Tamai H" first="Hiroshi" last="Tamai">Hiroshi Tamai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23790266</idno><idno type="pmid">23790266</idno><idno type="doi">10.1016/j.braindev.2013.05.007</idno><idno type="wicri:Area/PubMed/Corpus">001C75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C75</idno><idno type="wicri:Area/PubMed/Curation">001C75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C75</idno><idno type="wicri:Area/PubMed/Checkpoint">001966</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001966</idno><idno type="wicri:Area/Ncbi/Merge">000A64</idno><idno type="wicri:Area/Ncbi/Curation">000A64</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A64</idno><idno type="wicri:Area/Main/Merge">001D30</idno><idno type="wicri:Area/Main/Curation">001D16</idno><idno type="wicri:Area/Main/Exploration">001D16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinico-radiological spectrum of reversible splenial lesions in children.</title><author><name sortKey="Kashiwagi, Mitsuru" sort="Kashiwagi, Mitsuru" uniqKey="Kashiwagi M" first="Mitsuru" last="Kashiwagi">Mitsuru Kashiwagi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan. Electronic address: dbs003@art.osaka-med.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tanabe, Takuya" sort="Tanabe, Takuya" uniqKey="Tanabe T" first="Takuya" last="Tanabe">Takuya Tanabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Child Neurology, Tanabe Kadobayashi Children's Clinic, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Child Neurology, Tanabe Kadobayashi Children's Clinic</wicri:regionArea><wicri:noRegion>Tanabe Kadobayashi Children's Clinic</wicri:noRegion></affiliation></author><author><name sortKey="Shimakawa, Shuichi" sort="Shimakawa, Shuichi" uniqKey="Shimakawa S" first="Shuichi" last="Shimakawa">Shuichi Shimakawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Michiko" sort="Nakamura, Michiko" uniqKey="Nakamura M" first="Michiko" last="Nakamura">Michiko Nakamura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Murata, Shinya" sort="Murata, Shinya" uniqKey="Murata S" first="Shinya" last="Murata">Shinya Murata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Shabana, Kousuke" sort="Shabana, Kousuke" uniqKey="Shabana K" first="Kousuke" last="Shabana">Kousuke Shabana</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Shinohara, Jun" sort="Shinohara, Jun" uniqKey="Shinohara J" first="Jun" last="Shinohara">Jun Shinohara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Odanaka, Yutaka" sort="Odanaka, Yutaka" uniqKey="Odanaka Y" first="Yutaka" last="Odanaka">Yutaka Odanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Nagano Children's Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital, Japan; Department of Pediatrics, Nagano Children's Hospital</wicri:regionArea><wicri:noRegion>Nagano Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Matsumura, Hideki" sort="Matsumura, Hideki" uniqKey="Matsumura H" first="Hideki" last="Matsumura">Hideki Matsumura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Maki, Koh" sort="Maki, Koh" uniqKey="Maki K" first="Koh" last="Maki">Koh Maki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Okumura, Kenichi" sort="Okumura, Kenichi" uniqKey="Okumura K" first="Kenichi" last="Okumura">Kenichi Okumura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Okasora, Keisuke" sort="Okasora, Keisuke" uniqKey="Okasora K" first="Keisuke" last="Okasora">Keisuke Okasora</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Hirakata City Hospital</wicri:regionArea><wicri:noRegion>Hirakata City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tamai, Hiroshi" sort="Tamai, Hiroshi" uniqKey="Tamai H" first="Hiroshi" last="Tamai">Hiroshi Tamai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Osaka Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Osaka Medical College</wicri:regionArea><wicri:noRegion>Osaka Medical College</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain & development</title><idno type="eISSN">1872-7131</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Chemical Analysis</term><term>Brain Diseases (diagnosis)</term><term>Brain Diseases (etiology)</term><term>Brain Diseases (physiopathology)</term><term>Brain Diseases (therapy)</term><term>Child</term><term>Child, Preschool</term><term>Corpus Callosum (pathology)</term><term>Disease Progression</term><term>Electroencephalography</term><term>Female</term><term>Fever (complications)</term><term>Humans</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Prognosis</term><term>Recurrence</term><term>Retrospective Studies</term><term>Seizures, Febrile (diagnosis)</term><term>Seizures, Febrile (etiology)</term><term>Seizures, Febrile (physiopathology)</term><term>Seizures, Febrile (therapy)</term><term>Syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse chimique du sang</term><term>Corps calleux (anatomopathologie)</term><term>Crises convulsives fébriles ()</term><term>Crises convulsives fébriles (diagnostic)</term><term>Crises convulsives fébriles (physiopathologie)</term><term>Crises convulsives fébriles (étiologie)</term><term>Encéphalopathies ()</term><term>Encéphalopathies (diagnostic)</term><term>Encéphalopathies (physiopathologie)</term><term>Encéphalopathies (étiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Fièvre ()</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Nourrisson</term><term>Pronostic</term><term>Récidive</term><term>Syndrome</term><term>Électroencéphalographie</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Fever</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Brain Diseases</term><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Crises convulsives fébriles</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Crises convulsives fébriles</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Diseases</term><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Diseases</term><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Crises convulsives fébriles</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood Chemical Analysis</term><term>Child</term><term>Child, Preschool</term><term>Disease Progression</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Prognosis</term><term>Recurrence</term><term>Retrospective Studies</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse chimique du sang</term><term>Crises convulsives fébriles</term><term>Encéphalopathies</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Fièvre</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Nourrisson</term><term>Pronostic</term><term>Récidive</term><term>Syndrome</term><term>Électroencéphalographie</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, many cases of children presenting reversible splenial lesions during febrile illness (RESLEF) have been reported; however, their overall clinico-radiological features are unclear. To describe the clinico-radiological features, we retrospectively reviewed the etiology (pathogen), clinical course, laboratory data, magnetic resonance imaging and electroencephalography (EEG) findings, therapy, and prognosis of 23 episodes in 22 children (1 child recurred) who presented neurological symptoms, with RESLEF. The etiologies (pathogens) varied. Seizure occurred in 7 episodes, disturbance of consciousness (DC) in 13, and delirious behavior in 18. Serum sodium levels <136 mEq/L were observed in 18 episodes. Lesions outside the splenium were found in 4 cases. Slow waves were observed on EEG in 10 episodes. Methylprednisolone pulse therapy was given in 7 cases. No case resulted in neurological sequelae. Among 23 episodes, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) was diagnosed in 6 episodes, whereas non-MERS was observed in 17 episodes. No difference was observed in almost all the clinico-radiological features' data between the 2 groups. The largest differences were observed in the rate of purposeless movement, DC, extension of the abnormal lesions outside the splenium, and marked slowing of background activity on EEG. RESLEF exhibit a spectrum of clinico-radiological features. These results suggest that non-MERS and MERS both are a part of a larger pathological condition, which we have termed as RESLEF spectrum syndrome. Given the view that such a syndrome exists, the clinical characteristics and position of non-MERS and MERS become clear.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kashiwagi, Mitsuru" sort="Kashiwagi, Mitsuru" uniqKey="Kashiwagi M" first="Mitsuru" last="Kashiwagi">Mitsuru Kashiwagi</name></noRegion><name sortKey="Maki, Koh" sort="Maki, Koh" uniqKey="Maki K" first="Koh" last="Maki">Koh Maki</name><name sortKey="Matsumura, Hideki" sort="Matsumura, Hideki" uniqKey="Matsumura H" first="Hideki" last="Matsumura">Hideki Matsumura</name><name sortKey="Murata, Shinya" sort="Murata, Shinya" uniqKey="Murata S" first="Shinya" last="Murata">Shinya Murata</name><name sortKey="Nakamura, Michiko" sort="Nakamura, Michiko" uniqKey="Nakamura M" first="Michiko" last="Nakamura">Michiko Nakamura</name><name sortKey="Odanaka, Yutaka" sort="Odanaka, Yutaka" uniqKey="Odanaka Y" first="Yutaka" last="Odanaka">Yutaka Odanaka</name><name sortKey="Okasora, Keisuke" sort="Okasora, Keisuke" uniqKey="Okasora K" first="Keisuke" last="Okasora">Keisuke Okasora</name><name sortKey="Okumura, Kenichi" sort="Okumura, Kenichi" uniqKey="Okumura K" first="Kenichi" last="Okumura">Kenichi Okumura</name><name sortKey="Shabana, Kousuke" sort="Shabana, Kousuke" uniqKey="Shabana K" first="Kousuke" last="Shabana">Kousuke Shabana</name><name sortKey="Shimakawa, Shuichi" sort="Shimakawa, Shuichi" uniqKey="Shimakawa S" first="Shuichi" last="Shimakawa">Shuichi Shimakawa</name><name sortKey="Shinohara, Jun" sort="Shinohara, Jun" uniqKey="Shinohara J" first="Jun" last="Shinohara">Jun Shinohara</name><name sortKey="Tamai, Hiroshi" sort="Tamai, Hiroshi" uniqKey="Tamai H" first="Hiroshi" last="Tamai">Hiroshi Tamai</name><name sortKey="Tanabe, Takuya" sort="Tanabe, Takuya" uniqKey="Tanabe T" first="Takuya" last="Tanabe">Takuya Tanabe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23790266
|texte= Clinico-radiological spectrum of reversible splenial lesions in children.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23790266" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |